Isuzu i-280 and i-350 pickups are essentially Chevrolet Colorados and GMC Canyons wearing different nomenclature. According to Terry Maloney, President of Isuzu Motors America, GM and Isuzu collaborated on the original design of this vehicle, with Isuzu taking the lead on packaging, interior design, and powertrains, while GM worked on styling and prototype production. GM's versions hit the market in 2004, and the first Isuzus will be sold as 2006 models.

The i-280 is a two-wheel drive, extra-cab pickup equipped with a 2.8-liter four-cylinder engine that provides 175 horsepower and 185 lb.-ft. of torque. A five-speed manual transmission is standard and a four-speed automatic is optional. Isuzu's i-350 pickup is a four-wheel drive, four-door pickup featuring a 220-horsepower, 3.5-liter, five-cylinder engine that provides 225 lb.-ft. of torque. The four-speed automatic transmission is standard.